The first year of infection is the worst for most people, because they have more frequent outbreaks. Until the virus becomes less active, taking the medication on a suppressive basis can be very helpful. Of course certain people won’t need to do this, because they won’t have frequent outbreaks or their outbreaks will be manageable. A person who decides to take medication suppressively for a time may want to try stopping it at some point to see if the virus is still as active. If, after stopping the medication, that person continues to have very frequent outbreaks, then he or she will probably want to resume suppressive treatment. Otherwise, using the medication only to treat outbreaks might be the best approach. Taking these antiviral medications suppressively does not appear to cause the herpes virus to become resistant to them. Such resistance occurs only very rarely, in immunocompromised persons. Studies have shown that suppressive use of acyclovir for ten years has not been associated with either resistance or adverse side effects. There are no known effects on sperm production in men or on fertility in men or women.
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